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"Sebbene l’aspettativa di vita nei pazienti con IBD sia migliorata negli ultimi 15-20 anni, è preoccupante che, nonostante tutti i nostri progressi nel trattamento dell’IBD, l’aspettativa di vita sia ancora inferiore rispetto alle persone senza IBD," Benchimol ha detto a MedPage Today. "Inoltre, l’aspettativa di vita corretta per la salute, una misura della qualità della vita, è sostanzialmente inferiore nelle persone con IBD. Questo è rimasto stabile per le femmine o è diminuito per i maschi, quindi i nostri trattamenti non stanno ancora raggiungendo tutti gli obiettivi che speravamo."
Il divario nell’aspettativa di vita aggiustata per la salute tra quelli con e senza IBD era particolarmente ampio, ha detto, se valutato sia dal benessere generale che dall’effetto del dolore – nonostante l’introduzione durante il periodo di studio di due farmaci biologici, infliximab (Remicade, nel 2001) e adalimumab (Humira, nel 2004).
Lo studio di coorte retrospettivo ha attinto alle informazioni dai dati di indagini sanitarie amministrative, demografiche e sanitarie disponibili dai database dell’Ontario.
Per calcolare l’aspettativa di vita, i ricercatori hanno abbinato le persone con diagnosi di IBD a quelle senza utilizzare tabelle di vita mestruale basate sulla mortalità a 5 anni specifica per età e sesso per il 1996, 2000, 2008 e 2011. Hanno anche incorporato i dati dell’Health Utility Index (National Population Health Study e Canadian Community Health Survey) per stimare l’aspettativa di vita corretta per la salute per il 1996, 2000 e 2008.
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